Status:
COMPLETED
ABCA3 Gene and RDS in Late Preterm and Term Infants
Lead Sponsor:
Children's Hospital of Chongqing Medical University
Conditions:
Respiratory Distress Syndrome, Newborn
Eligibility:
All Genders
Up to 6 years
Brief Summary
Respiratory distress syndrome (RDS) is the most common respiratory cause of mortality and morbidity in very preterm infants, but it also could be seen in late preterm and term infants. Some genetic me...
Eligibility Criteria
Inclusion
- infants ≥34 weeks' gestation
- meet the fatal respiratory distress syndrome as following: (1) manifestations and chest radiograph are compatible with RDS; (2) at least 7days on invasive ventilation with FiO2 ≥60%, or persistent hypoxemic respiratory failure on FiO2 100% regardless of duration of invasive ventilation
- undergone exome sequencing
Exclusion
- culture-positive sepsis
- cardiopulmonary malformations
- pulmonary hypoplasia
- known surfactant mutations such as SFTPB, SFTPC, CHPT1, LPCAT1 and PCYT1B were excluded.
Key Trial Info
Start Date :
May 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT04137783
Start Date
May 1 2019
End Date
December 1 2020
Last Update
August 6 2021
Active Locations (1)
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1
Children's hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400014