Status:
COMPLETED
Effects of Two Weeks of 5:2 Intermittent Energy Restriction on Basal and Postprandial Metabolism
Lead Sponsor:
University of Nottingham
Conditions:
Weight Loss
Eligibility:
All Genders
20-35 years
Phase:
NA
Brief Summary
Worldwide, a third of adults were overweight in 2016, and 13% were obese. Excess energy intake results in weight gain. Excess fat increases the risk of disease (eg. cardiovascular diseases, type 2 dia...
Detailed Description
Once participants have consented to be screened, they will come to the lab for a medical screening. If the medical screening is satisfactory, all participants will be asked to undergo a one-week pre-s...
Eligibility Criteria
Inclusion
- ages between 20 - 35 years;
- healthy with a body mass index (BMI) between 20 and 27 kg·m-2;
- a waist circumference \< 94 cm for males and \< 80 cm for females;
- ability to give informed consent
Exclusion
- smoking (including vaping);
- regularly skipping breakfast;
- any metabolic (e.g. diabetes), endocrine (e.g. hyperthyroidism) or cardiovascular (e.g. heart or blood) abnormalities including hypertension or heart failure;
- clinically significant abnormalities on screening including ECG abnormalities;
- taking routine medication that may alter cardiovascular function and blood flow (e.g. blood pressure-lowering drugs or drugs that cause hypertension);
- taking medication for diabetes or having diabetes;
- a history of substance abuse in the last six months;
- well-trained individuals with PAL\>2.00;
- on an energy-restricted diet;
- high alcohol consumption (\<3-4 units/d for men; \<2-3 units/d for women);
- females who are pregnant or lactating and with irregular menstrual cycles;
- self-reported allergy, intolerance or strong dislike of foods or drinks to be offered for the test breakfast, pasta meal or during the intervention period;
- Beck Depression Inventory (BDI) score \>10, and Eating Attitudes Test (EAT-26) score \>20 as self-reported markers of symptoms and concerns characteristic of depression and eating disorders, respectively.
Key Trial Info
Start Date :
October 18 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 22 2019
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04138160
Start Date
October 18 2018
End Date
May 22 2019
Last Update
November 21 2019
Active Locations (1)
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1
University of Nottingham
Nottingham, Select State..., United Kingdom, NG7 2UH