Status:
COMPLETED
Dutch Cangrelor Registry
Lead Sponsor:
Isala
Conditions:
STEMI - ST Elevation Myocardial Infarction
NSTEMI - Non-ST Segment Elevation MI
Eligibility:
All Genders
18-110 years
Brief Summary
Cangrelor is a fast and directly acting platelet aggregation inhibitor. It is potentially indicated for several types of patients who are undergoing PCI. A nationwide cangrelor registry has up until n...
Eligibility Criteria
Inclusion
- Age ≥18 years
- One of the following criteria:
- Patients naïve for P2Y12 inhibition undergoing PCI
- Patients with suboptimal P2Y12 inhibition undergoing PCI (patients who vomited after P2Y12 loading, out of hospital cardiac arrest (OHCA) patients with restoration of spontaneous circulation (ROSC), patients loaded with P2Y12 inhibitors though platelet inhibition still insufficient (\<2 hours after oral loading dose)
- (N)STEMI patients loaded with P2Y12 inhibitors with large thrombus burden (thrombus grade 4 or 5) on initial coronary angiography (CAG) and undergoing primary PCI with expected insufficient P2Y12 inhibition
Exclusion
- Patients on current/chronic treatment with P2Y12 inhibitors
- Patients (pre) treated with a GPI
- Patients with recent major bleeding complications or contraindication to dual antiplatelet therapy:
- hypersensitivity or allergy to and known contra-indication for aspirin, clopidogrel, ticagrelor or cangrelor
- history of major clinical bleeding or known coagulopathy
- active bleeding
- history of intracerebral mass, aneurysm, arteriovenous malformation, or hemorrhagic stroke
- known severe liver dysfunction
- Patients that received any organ transplant or are on a waiting list for any organ transplant
- Patients undergoing dialysis
- Pregnant or lactating female
- Patients currently participating in another investigational drug or device study
Key Trial Info
Start Date :
December 17 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 24 2020
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT04138641
Start Date
December 17 2019
End Date
July 24 2020
Last Update
July 28 2020
Active Locations (1)
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1
R.S. Hermanides
Zwolle, Overijssel, Netherlands, 8025AB