Status:
TERMINATED
Platelet Bioenergetics in TBI
Lead Sponsor:
Kevin Hatton
Conditions:
Brain Injuries, Traumatic
Eligibility:
All Genders
18-50 years
Brief Summary
This is a prospective study enrolling 5 patients with a diagnosis of traumatic brain injury (TBI) without polytrauma and 5 patients with TBI with polytrauma admitted to the University of Kentucky (UK)...
Detailed Description
Traumatic brain injury (TBI) is used to describe a myriad of primary and secondary brain-related injuries related to trauma. Clinically, moderate-to-severe brain injury results in early coagulopathy, ...
Eligibility Criteria
Inclusion
- Patients must have moderate to severe traumatic brain injury (Glasgow Coma Scale (GCS) 3-13) to be enrolled in the TBI or TBI with trauma groups.
- Patients enrolled in the TBI with polytrauma group must also exhibit polytrauma including concomitant traumatic brain injury, major trauma to the chest, abdomen, pelvis or extremities.
- Patients must be greater than or equal to 18 years of age and must be less than or equal to 50 years of age.
- Patients must be able to cooperate for a detailed neurologic exam.
- Patients must be consented and undergo first blood sampling within the first 12 hours (+/- 2 hours) after their traumatic brain injury to be enrolled in the TBI or TBI with trauma groups.
- Patients must be expected to survive to discharge, as assessed by their admitting neurosurgery team
Exclusion
- For the control group only, patients who have experienced a TBI in the last 6 months.
- Diagnosis of platelet diseases or disorders, such as thrombocytopenia, thrombocytosis, or Von Willebrand disease.
- Platelet transfusion within the last six months.
- Comorbid regimen of Metformin within the last 6 months.
Key Trial Info
Start Date :
February 13 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 13 2020
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT04271059
Start Date
February 13 2020
End Date
February 13 2020
Last Update
October 28 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Kentucky Medical Center
Lexington, Kentucky, United States, 40536