Status:
COMPLETED
The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries
Lead Sponsor:
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Conditions:
Hyperbilirubinemia
Hepatic Impairment
Eligibility:
All Genders
19-80 years
Brief Summary
In a prospective observational study during the six-month duration, coronary artery bypass graft surgery (CABG) and valve repair surgery (mitral, mitral, and aortic valve and/or tricuspid valve) patie...
Detailed Description
There are a series of pathophysiological changes in patients undergoing open-heart surgeries with cardiopulmonary bypass (CPB) that causes liver hypoperfusion, centrilobular sinusoid ischemia, and sub...
Eligibility Criteria
Inclusion
- Patients undergoing open-heart surgery with CPB,
- Patients between the ages of 19 to 80,
- American Society of Anesthesiologist (ASA) status of 2 and 3,
- Preoperative ejection fraction (EF) greater than 30%.
- There were five different open-heart surgery group of patients in this study. The groups include; coronary artery bypass grafting (CABG), mitral valvular replacement, aortic valvular replacement, combined mitral and aortic valve replacement, combined mitral, aortic and/or tricuspid valve replacements.
Exclusion
- Both CABG and valve replacement,
- Resection of a ventricular or aortic aneurysm,
- Transplantation or another surgical procedure,
- Reoperation of valvular repair surgery, patients with preoperative ejection fraction less than 30%,
- Preoperative hyperbilirubinemia defined as total bilirubin concentration of more than 3 mg/dL,
- Preoperative congestive heart failure, preoperative renal dysfunction (serum creatinine greater than 1.3 mg/dL),
- Chronic oliguria/anuria requiring dialysis,
- Preoperative American Society of Anesthesiologist (ASA) status of 4,
- History of pancreatitis or current corticosteroid treatment.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
340 Patients enrolled
Trial Details
Trial ID
NCT04271098
Start Date
January 1 2012
End Date
September 1 2012
Last Update
February 20 2020
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