Status:
RECRUITING
Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
Lead Sponsor:
University of Calgary
Conditions:
Postural Tachycardia Syndrome
Orthostatic Intolerance
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important eff...
Detailed Description
The effects of hypercapnia on cerebral blood flow velocity and arterial blood pressure in healthy subjects lead to an increase in orthostatic tolerance, peak HR and time to peak HR compared with normo...
Eligibility Criteria
Inclusion
- Physician diagnosis of Postural Tachycardia Syndrome (POTS)
- Age 18-60 years
- Male and Female
- Non - smokers.
- Able and willing to provide informed consent.
- Ability to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB.
Exclusion
- Overt cause for postural tachycardia, i.e., acute dehydration
- Participants with somatization or severe anxiety symptoms will be excluded
- Pregnant
- Inability to tolerate mask for the duration of the study
- Subjects who require portable oxygen at rest or with exercise
- Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
- Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.
Key Trial Info
Start Date :
February 2 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04271878
Start Date
February 2 2022
End Date
December 1 2026
Last Update
May 9 2024
Active Locations (1)
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1
University of Calgary
Calgary, Alberta, Canada, T2N 4Z6