Status:
COMPLETED
HOT HMV 2: A Phase 4 Study
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
COPD Exacerbation
Eligibility:
All Genders
18+ years
Brief Summary
Smoking related lung disease or Chronic Obstructive Pulmonary Disease (COPD) is characterised by periods of worsening symptoms termed exacerbations. In some patients these may be severe enough to requ...
Detailed Description
Following publication of the home oxygen therapy-home mechanical ventilation (HOT-HMV) trial, the purpose of this study is to evaluate the clinical service delivery of home non-invasive ventilation (N...
Eligibility Criteria
Inclusion
- Patient suspected or with proven diagnosis of COPD
- Admission to hospital with life-threatening exacerbation of COPD requiring acute NIV (at admission evidence of decompensated Chronic Respiratory Insufficiencies (PaCO2 \> 6kPa, pH \<7.35)
- Arterial partial pressure of carbon dioxide (PaCO2) \> 6kPa at discharge from hospital
- Discharge from hospital without combined home non-invasive ventilation and home oxygen therapy
- Patient willing to consider home non-invasive ventilation in addition to home oxygen therapy
- Patient suitable for home oxygen therapy (appropriate risk assessment)
Exclusion
- Patient already established on home non-invasive ventilation and home oxygen therapy
- Patient unable to support home non-invasive ventilation e.g. unable to apply mask, lacking social support
- Patient on palliative care pathway
- Patient outside of usual catchment area for Lane Fox Respiratory Service
Key Trial Info
Start Date :
May 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 30 2021
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT04272879
Start Date
May 1 2018
End Date
April 30 2021
Last Update
October 1 2021
Active Locations (1)
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1
Guys and St Thomas NHS Foundation
London, United Kingdom, SE1 7EH