Status:
COMPLETED
Effect of Exercise on Biomarkers in SCT
Lead Sponsor:
St. Louis University
Collaborating Sponsors:
American Society for Clinical Laboratory Science
Conditions:
Sickle Cell Trait
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal fun...
Detailed Description
Subjects with sickle cell trait and healthy controls will be subjected to a single bout of moderate, controlled exercise on a treadmill. Blood and urine samples will be collected before exercise, imme...
Eligibility Criteria
Inclusion
- Sickle Cell Trait Group (AS)
- Health subjects with sickle cell trait (AS)
- Ages 18-70 years
- Control group (AA)
- Healthy subjects without sickle cell trait (AA)
- Ages 18-70 years
Exclusion
- Sickle Cell Trait group (AS) AND healthy controls (AA).
- Subjects will be excluded if they:
- weigh less than 110 pounds,
- are pregnant,
- have hemoglobinopathies (other than sickle cell trait) as determined by Hb electrophoresis,
- have other self-reported conditions known to cause blood coagulation activation, myocyte destruction, hemolysis, chronic inflammation, or renal disease
- any condition that places subjects at risk during exercise.
Key Trial Info
Start Date :
December 27 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04273022
Start Date
December 27 2021
End Date
December 31 2024
Last Update
January 28 2025
Active Locations (1)
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1
Saint Louis University
St Louis, Missouri, United States, 63104-1111