Status:

UNKNOWN

The Microbiome of Pancreatic Cancer: "PANDEMIC" Study

Lead Sponsor:

Azienda Ospedaliera Universitaria Integrata Verona

Conditions:

Microbial Colonization

Pancreas Cancer

Eligibility:

All Genders

18-65 years

Brief Summary

Microbiome in patients affected by pancreatic ductal adenocarcinoma may present specific and identifiable patterns. These variations could affect the surgical outcome and increase the risk of life-thr...

Detailed Description

Pancreatic cancer is predicted to become the second leading cause of cancer-related death in the western world by 2030. Patients still have a poor prognosis, and a complete surgical resection provides...

Eligibility Criteria

Inclusion

  • age between 18 and 65 years;
  • PDAC lesion of the pancreatic head confirmed by preoperative histology or cytology;
  • Scheduled for elective PD;
  • ASA score \< 4
  • The ability of the subject to understand the character and individual consequences of the clinical trial
  • Written informed consent

Exclusion

  • Patients with a degenerated pancreatic cyst lesion
  • Neoadjuvant treatment (both radio and chemotherapy)
  • Other current malignancies
  • Antibiotic therapy during 4 weeks before surgery
  • History of gastrointestinal tract resections or chronic gastrointestinal diseases
  • Pregnant or breastfeeding patients
  • Patients undergoing emergency surgery
  • ASA score \> 4
  • Impaired mental state or language problems

Key Trial Info

Start Date :

February 1 2020

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2024

Estimated Enrollment :

20 Patients enrolled

Trial Details

Trial ID

NCT04274972

Start Date

February 1 2020

End Date

December 31 2024

Last Update

January 17 2023

Active Locations (1)

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AOUI Verona

Verona, Italy, 37124