Status:
UNKNOWN
Neurotoxicity of Anesthesia in Middle Aged Patients
Lead Sponsor:
Tanta University
Conditions:
Anesthesia; Adverse Effect
Eligibility:
All Genders
18-50 years
Brief Summary
for the last 20 years, the increasing reports from non-human studies have raised suspicion that general anesthetics may cause neurotoxic changes in the developing brain that lead to adverse neurodevel...
Detailed Description
the primary inhibitory neurotransmitter GABA is found in neuronal synapses involving olfactory bulb. So, the involvement of common GABA pathway implies a possible interaction of general anesthetics wi...
Eligibility Criteria
Inclusion
- patients aged 18-50 years
- both sex
- American society of Anesthesiologists' physical status I and II
- elective surgery of duration 90-120 minutes
Exclusion
- patients's refusal
- recent airway infection
- allergic rhinitis
- nasal polyps
- history of alcoholism
- smoking
- pregnancy
- menstruating female
- mental retardation
- psychiatric illness
- neurosurgical or oto-rhino-laryngeal surgery
- history of olfactory deficits or cognitive impairment
- CNS disease e.g. epilepsy
- history of first degree relative with alzheimer's disease,dementia, or cognitive dysfunction
- those who are unable to answer the tests themselves
Key Trial Info
Start Date :
March 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT04275531
Start Date
March 1 2021
End Date
September 1 2022
Last Update
March 15 2022
Active Locations (1)
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1
Tanta University, Faculty of Medicine
Tanta, Egypt, 31527