Status:
COMPLETED
Study of PRP in Women With Evidence of Diminished Ovarian Reserve
Lead Sponsor:
Center for Human Reproduction
Conditions:
Diminished Ovarian Reserve
Ovarian Failure
Eligibility:
FEMALE
21-52 years
Phase:
NA
Brief Summary
The hypothesis of the study is that ovaries of women with a history of poor response to ovulation induction may benefit from exposure to growth factors known to be present in Platelet Rich Plasma (PRP...
Detailed Description
The hypothesis of the study is that ovaries of women with a history of poor response to ovulation induction may benefit from exposure to growth factors known to be present in PRP. Autologous Platelet...
Eligibility Criteria
Inclusion
- Women with failure to respond well to ovulation induction by having fewer than 1 cleavage stage embryo in response to past ovulation induction who do not qualify for the PRP4POI study
- Age 54 years and under.
- FSH \> 12
- AMH \< 1.1
- -No Aspirin or Motrin for one week before treatment
Exclusion
- Age \> 54 years
- Marked thrombocytopenia
- Blood diseases
- Hypofibrinogenemia
- Hemodynamic instability
- Anticoagulant or antiaggregant treatment
- Oncological diseases (specially, skeletal system and blood)
- Sepsis
- Acute and chronic infectious diseases
- Autoimmune diseases, for example, lupus erythematosus, etc.
- Relative contraindications for PRP
- Chronic liver diseases in the exacerbation phase
- Chronic intoxication against the background of long-term use of alcohol, addictive drugs, an administration of potent medications
- Use of steroidal anti-inflammatory drugs in less than 2 days before drawing the blood, an injection of corticosteroids in little less than 2 weeks before the procedure
- Pregnancy
- Inflammatory skin diseases, chronic dermatosis in the exacerbation phase, for example, psoriasis, atopic eczema, etc.
Key Trial Info
Start Date :
October 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2024
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04275700
Start Date
October 1 2018
End Date
September 1 2024
Last Update
May 7 2025
Active Locations (1)
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1
Center For Human Reproduction
New York, New York, United States, 10021