Status:
ACTIVE_NOT_RECRUITING
Cognitive Prefrail and Frailty, and Motoric Cognitive Risk Syndrome: Prevalence and Association With Incident Adverse Health Events
Lead Sponsor:
Jewish General Hospital
Conditions:
Frailty
Motoric Cognitive Risk Syndrome
Eligibility:
All Genders
45-85 years
Brief Summary
We defined a new and early condition in the spectrum of cognitive frailty: the "cognitive-prefrailty" which is a combination of prefrailty stage and subjective cognitive impairment (SCI). This study a...
Detailed Description
Background Cognitive frailty is the simultaneous presence of both physical frailty and cognitive impairment, excluding concurrent dementia. This condition confers a greater risk of incident cognitive ...
Eligibility Criteria
Inclusion
- participants of the CLSA with baseline assessment (tracking and comprehensive assessment) and first 18-month follow-up assessment
- age \> 50
Exclusion
- no information which may directly or indirectly determine the occurrence of incident adverse health events (falls and related injuries, depression, functional decline, motoric cognitive risk syndrome, cognitive decline and dementia)
- age \< 50 and demented LCSA participants if they meet the following criteria:
- History of dementia or Alzheimer's disease and/or use of anti-dementia drugs (i.e., Donepezil, Rivastigmine, Galentamine, regardless the dose taken)
- Objective cognitive impairment (i.e., performance ≥2 SDs below the age-appropriate mean) in two cognitive domains (i.e., episodic memory and executive function) and abnormal scores on the ADL and IADL scales
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2025
Estimated Enrollment :
30000 Patients enrolled
Trial Details
Trial ID
NCT04275817
Start Date
December 1 2020
End Date
February 1 2025
Last Update
April 5 2024
Active Locations (1)
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1
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2