Status:
COMPLETED
Exploring the Effect of Inorganic Nitrates on the Human Microvascular Physiology - a Pilot Study.
Lead Sponsor:
Sheffield Hallam University
Collaborating Sponsors:
University of Sheffield
University of Nottingham
Conditions:
Aging
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
We conducted a randomised, placebo-controlled, double blind, cross-over, trial to examine the short-term effect of concentrated beetroot juice on vascular outcomes in a young (18-35 years) and older g...
Detailed Description
Cardiovascular disease (CVD) is the largest cause of global mortality accounting for over twenty-nine percent of all deaths with coronary heart disease and stroke projected to become the global leadin...
Eligibility Criteria
Inclusion
- non-smoking,
- healthy (defined by the absence of overt chronic diseases that could affect their micro- and macro- vascular function - e.g. chronic venous insufficiency, systemic sclerosis, hypercholesterolemia, diabetes, cardiovascular disease - as determined by a medical history questionnaire),
- male or female adults aged between 18 and 35 years (Group A) and 55 and 75 years (Group B).
- normotensive (systolic blood pressure (SBP) between 115 and 140 mmHg and diastolic blood pressure (DBP) between 75 and 90 mmHg) with body mass index (BMI) 18-30 kg/m2.
Exclusion
- taking medications interfering with the study outcomes,
- have lost more than 3kg in the month before the study,
- wearing complete dentures and diagnosis of inflammatory oral diseases.
Key Trial Info
Start Date :
June 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2018
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04276766
Start Date
June 1 2015
End Date
January 1 2018
Last Update
February 19 2020
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