Status:
UNKNOWN
HA-WBRT vs SRS in Patients With Multiple Brain Metastases
Lead Sponsor:
Medical University Innsbruck
Conditions:
Brain Metastases
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This study compares the effectiveness and safety of two radiation treatment techniques for patients with multiple brain metastases.
Detailed Description
For patients suffering from multiple brain metastases whole brain radiation therapy still constitutes a standard therapy. However, because of the risk of neurocognitive side effects as well as reduced...
Eligibility Criteria
Inclusion
- At least 4 and not exceeding 15 brain metastases not exceeding a combined total volume of 25ml and not previously treated with radiotherapy
- KPI ≥ 70, ECOG ≤ 2
- Age ≥ 18 years, Male or female
Exclusion
- Neuroendocrine, SCLC, germinoma or lymphoma histology
- Brain stem metastasis
- Life expectancy \< 3 months
- Suspicion of meningeosis carcinomatosa
- Previous WBRT
- Inability to participate in radiologic follow-up, contraindication to MR imaging (e.g. not MRI compatible pacemaker, severe claustrophobia)
- Inability to participate in neurocognitive function testing, insufficient German language skills, aphasia, graphomotor impairment, insufficient vision, insufficient attention span
- Pregnancy, nursing or unwillingness to prevent pregnancy using effective methods of contraception during treatment
- Known abuse of medication, drugs or alcohol
- Known severe dementia (z-score \< 2) or major cognitive function disorder that is not caused by intracranial tumour
- Known clinical depression or psychotic disorder
Key Trial Info
Start Date :
February 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2023
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04277403
Start Date
February 15 2020
End Date
February 1 2023
Last Update
September 5 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical University Innsbruck
Innsbruck, Austria, 6020