Status:
RECRUITING
Ovarian Function Following Intraovarian Injection of PRP
Lead Sponsor:
Center for Human Reproduction
Conditions:
Diminished Ovarian Reserve
Diminished Ovarian Reserve Due to Advanced Maternal Age
Eligibility:
FEMALE
21-44 years
Phase:
NA
Brief Summary
Consenting women with evidence of poor ovarian reserve will be randomly assigned to treatment with either Platelet Rich Plasma (PRP) or Platelet Poor Plasma (PPP).
Detailed Description
As women age oocytes are gradually depleted with a consequent progressive loss of ovarian function and fertility. When a woman's follicle cohort falls below a critical level, she enters a transitional...
Eligibility Criteria
Inclusion
- fewer than 6 oocytes in response to past ovulation induction
- desire to establish a pregnancy using IVF
- Age 44 years and under.
- FSH \> 12
- AMH \< 1.0
- No Aspirin or Motrin for one week before treatment
Exclusion
- Age \> 45 years
- Marked thrombocytopenia
- Blood diseases
- Hypofibrinogenemia
- Hemodynamic instability
- Anticoagulant or antiaggregant treatment
- Oncological diseases (specially, skeletal system and blood)
- Sepsis
- Acute and chronic infectious diseases
- Autoimmune diseases, for example, lupus erythematosus, etc.
Key Trial Info
Start Date :
February 24 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04278313
Start Date
February 24 2020
End Date
December 31 2026
Last Update
December 26 2025
Active Locations (1)
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1
Center for Human Reproduction
New York, New York, United States, 10021