Status:
TERMINATED
Molecular Biomarkers for Sepsis
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborating Sponsors:
Swiss Personalized Health Network (SPHN)
Personalized Health and Related Technologies (PHRT) initiative of ETH Zürich
Conditions:
Sepsis
Severe Community-acquired Pneumonia (sCAP)
Eligibility:
All Genders
18+ years
Brief Summary
This multi-center observational case-control study in Intensive Care Unit (ICU) patients is to identify novel biomarkers allowing to recognize severe community acquired pneumonia (sCAP) -associated se...
Eligibility Criteria
Inclusion
- Admission to the ICU of one of the participating centers.
- Cases: severe community acquired pneumonia with requirement for ICU admission.
- Controls: Clinical phenotype of inflammation not due to suspected sepsis In addition, control patients will be patients with fever \>38°C, CRP \>100mg/L, no infection focus expected in ≥ 24h.
- All required sample types can most likely be collected within the first 24h visits.
- Expected ICU stay of more than 24h.
Exclusion
- Admission to the hospital within the prior 14 days.
- Patients with psychosis
- Evidence of a hospital acquired pneumonia.
- One of the following respiratory conditions: Acute exacerbation of chronic obstructive pulmonary disease (COPD) or bronchiectasis, acute severe asthma, aspiration pneumonia, tuberculosis, clinical suspected viral pneumonia without bacterial infection, cardiogenic pulmonary oedema.
- Patients with an acute respiratory distress Syndrome (ARDS).
- Patient which can be managed as outpatients and do not require an ICU.
- Patient where a transmission to another institution is likely within the next 24h.
- Documented rejection of the general consent or participation to research in general.
- Patients with a palliative situation and a life expectancy due to other diseases (e.g. progressed cancer) less than 28 days.
Key Trial Info
Start Date :
February 16 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2022
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT04280354
Start Date
February 16 2022
End Date
July 31 2022
Last Update
May 9 2024
Active Locations (15)
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1
Clinical Bacteriology and Mycology, University Hospital Basel
Basel, Switzerland, 4031
2
Infectious Diseases and Hospital Epidemiology, University Hospital Basel
Basel, Switzerland, 4031
3
Intensive Care Unit; University Hospital Basel
Basel, Switzerland, 4031
4
Institute for Infectious Diseases, University of Bern
Bern, Switzerland, 3001