Status:
COMPLETED
Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock
Lead Sponsor:
University Hospital, Angers
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study evaluates if improvement of renal resistive index when mean arterial pressure increase (at 65 mmHg to 85 mmHg) in early phase of septic shock is predictive of better renal survival.
Detailed Description
Learned societes (survival sepsis campaign and ESICM) are currently recommending a mean arterial pressure (MAP) target at 65 mmHg in septic shoc with a potential increase to 85 mmHg in patients with m...
Eligibility Criteria
Inclusion
- adult patients (≥ 18 ans)
- Admitted to the intensive care unit of Angers with
- arterial hypotension requiring the etablishment of catecholamines
- In a context of proven or suspected sepsis, whaterver the cause of this infection.
- norepinephrine dose ⩾ 0.1µg/kg/min
- After 2 hours of stabilization at 65 mmHg of mean arterial pressure
Exclusion
- Pre-existing chronic renal failure (glomerular filtration rate \< 60 mL/min with MDRD)
- Solitary kidney (anatomical or functional)
- History of united or bilateral stenosis of the renal arteries
- decision to stop or limit treatment
- patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \<7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \> 40 mmol/l and oliguria/anuria \> 72 h.)
- pregnant, lactating or parturient woman
- patient deprived of liberty by judicial or administrative decision
- patient with psychiatric compulsory care
- patient subject to legal protection measures
Key Trial Info
Start Date :
June 6 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 4 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04281277
Start Date
June 6 2020
End Date
February 4 2025
Last Update
October 1 2025
Active Locations (1)
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1
CHU Angers. Médecine Intensive Réanimation et médecine hyperbare
Angers, France, 49100