Status:
UNKNOWN
Optimising 3D pH-Weighted CEST MRI in Acute Ischaemic Stroke (CEST in Stroke)
Lead Sponsor:
King's College Hospital NHS Trust
Collaborating Sponsors:
King's College London
Conditions:
Stroke, Acute
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
CEST in Stroke is an observational magnetic resonance imaging (MRI) study in acute ischaemic stroke patients. Ischaemic stokes are the most common type of stroke and occur when a blood clot blocks the...
Detailed Description
CEST in Stroke is an observational magnetic resonance imaging (MRI) study in acute ischaemic stroke patients. Ischaemic stokes are the most common type of stroke and occur when a blood clot blocks the...
Eligibility Criteria
Inclusion
- Clinical diagnosis of acute anterior circulation ischaemic stroke
- Within 24 hours of symptom onset as defined by time since last known well
- Measurable neurological deficit (i.e. impairment of one or more of the following: language, motor function, cognition, gaze, vision, neglect)
- National Institutes of Health Stroke Scale (NIHSS) score of \>= 10
- \>= 18 years old
- Written informed consent from patient, legal representative or consultee
Exclusion
- Any contraindication to MRI (e.g. cardiac pacemaker)
- Clinical diagnosis of posterior circulation ischaemic stroke
- NIHSS \<10
- Evidence of intracranial haemorrhage or significant non-stroke intracranial pathology (including CNS \[central nervous system\] neoplasm) on CT
- Seizure at onset of symptoms unless CT identifies positive evidence of significant brain ischaemia (e.g. arterial occlusion, early ischaemic change)
- Planned or anticipated intravenous thrombolysis or endovascular re-perfusion strategies
- Pregnancy
- Known allergy to MRI contrast agent
Key Trial Info
Start Date :
June 13 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2023
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT04282330
Start Date
June 13 2018
End Date
April 30 2023
Last Update
April 5 2022
Active Locations (1)
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1
King's College Hospital
London, United Kingdom, SE5 9RS