Status:
UNKNOWN
Screening of NASH in Oupatients Followed in Various Hospital Specialty Clinics at the University Hospital of Strasbourg
Lead Sponsor:
University Hospital, Strasbourg, France
Conditions:
Nonalcoholic Fatty Liver Disease
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the present study is to assess, by using a simple algorithm combining FIB-4 and Fibroscan, the prevalence of NASH with advanced fibrosis in outpatients followed in various hospital specialt...
Eligibility Criteria
Inclusion
- age ≥ 18 years
- outpatients followed at specialty clinics in HUS and at risk of NAFLD: with at least one metabolic risk factor (overweight, diabetes mellitus, hypertension, hypertriglyceridemia) and/or elevated transaminases and/or liver steatosis on US.
- endocrinology cohort : type 2 diabetes patients
- infectious disease cohort : HIV positive patients
- rheumatology cohort : patients with psoriasis, gout or rheumatoid arthritis
- nephrology cohort : patients with chronic kidney disease such as diabetic nephropathy or hypertensive nephropathy, including those receiving hemodialysis.
- cardiology cohorts: patients with history of angina, myocardial infarction, stroke or arteritis of lower limbs.
- internal medicine cohort: patients with auto immune systemic diseases such as lupus, sclerosis or rheumatoid arthritis.
- subjects who have given their informed consent
- Subjects affiliated to a social security system
Exclusion
- alcohol consumption \> 30g/d in male or \> 20g/d in female in the past 6 months
- history of chronic viral hepatitis
- history of liver auto immune disease, genetic hemochromatosis, Wilson disease
- biliary disease, bile duct obstruction
- drug-induced liver injury
- secondary liver cancer or other active cancer
- organ graft
- use of medications associated with secondary NAFLD (corticosteroids, tamoxifen, amiodarone, methotrexate).
- congestive heart failure
- AIDS
- pregnancy, breastfeeding
- no information could be given to the patient (subject faces emergency situation, comprehension difficulties, etc.)
- patient under guardianship
- patients under judicial protection
Key Trial Info
Start Date :
August 14 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2022
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT04282447
Start Date
August 14 2020
End Date
May 1 2022
Last Update
August 27 2020
Active Locations (1)
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1
Les Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67091