Status:
COMPLETED
Dynamic Parameters in Evaluation of Fluid Responsiveness
Lead Sponsor:
Charles University, Czech Republic
Conditions:
Hypovolemia
Hypotension
Eligibility:
All Genders
18+ years
Brief Summary
Intravenous infusion of fluids in patients after surgery is a very important part of treatment. However, administering too much or too little fluid can lengthen the stay in the intensive care unit or ...
Detailed Description
Adequate fluid therapy is one of the most important variables influencing patient outcome in intensive care. Fluid therapy should be tailored to the individual needs of each patient. Static parameters...
Eligibility Criteria
Inclusion
- patients after elective coronary artery bypass grafting
- hypovolemia indicated for volumotherapy by the attending physician based on clinical and laboratory signs (ScvO2 under 65 % with serum lactate above 2 mmol/l, increase of vasopressoric support with CVP under 5 mmHg)
- intubated and ventilated patients
- sedation without spontaneous breathing activity
- no pulmonary pathology on X-ray after surgery
- normal systolic and diastolic function of both ventricles (left ventricular ejection fraction above 50 %, TAPSE of the right ventricle above 20 mm, FAC of the right ventricle above 30 %)
- informed consent signed before surgery
Exclusion
- aggresive artificial ventilation (PEEP above 10 cmH2O, Pmax above 30 cm H2O)
- ARDS, pneumothorax, fluidothorax
- hemodynamically significant valvular disease
- atrial fibrillation or other arrhythmia with irregular heartbeat
- intraabdominal hypertension with pressures above 15 mmHg
- open thorax
- bad echogenicity
Key Trial Info
Start Date :
February 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04283851
Start Date
February 1 2020
End Date
July 1 2022
Last Update
March 7 2023
Active Locations (1)
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1
Dept of Anaesthesia and Intensive Care, General University Hospital, 1st Medical Faculty, Charles University
Prague, Czechia, 120 00