Status:
COMPLETED
Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings
Lead Sponsor:
Medecins Sans Frontieres, Spain
Collaborating Sponsors:
Mahidol Oxford Tropical Medicine Research Unit
Gadjah Mada University
Conditions:
Sepsis
Eligibility:
All Genders
28-5 years
Brief Summary
Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford. The primary objective is to develop a risk prediction algorithm, combining measurement...
Detailed Description
Background Febrile illnesses are amongst the most common reasons that parents seek non-routine healthcare for their children and a proportion progress to severe disease with substantial risk of morta...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- The participant may enter the study if ALL of the following apply:
- Caretaker is willing and able to give informed consent for participation in the study;
- Aged \> 28 days and \< 5 years \[day of birth = Day 1\];
- Axillary temperature at presentation ≥ 37.5°C OR axillary temperature at presentation \< 35.5°C OR history of fever in last 24h;
- Onset of illness ≤ two weeks.
- Exclusion Criteria
- The participant may not enter the study if ANY of the following apply:
- Accident or trauma is the cause for child's presentation;
- Presentation ≤ 72 hours after routine immunisations;
- Known chronic medical condition including immunosuppression (for example, oncological conditions, HIV infection, thalassaemia, current steroid use), active chronic infection (for example, tuberculosis, hepatitis B virus), active cardiorespiratory conditions (for example, symptomatic or currently medicated congenital heart disease, cardiomyopathy or bronchiectasis);
- Admission to any health facility during the current illness;
- Previously enrolled in the study for a different acute illness;
- Receipt of \> 15 minutes of inpatient treatment.
Exclusion
Key Trial Info
Start Date :
March 5 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2022
Estimated Enrollment :
3433 Patients enrolled
Trial Details
Trial ID
NCT04285021
Start Date
March 5 2020
End Date
November 30 2022
Last Update
April 24 2023
Active Locations (6)
Enter a location and click search to find clinical trials sorted by distance.
1
MSF Goyalmara Green Roof Hospital
Cox’s Bāzār, Bangladesh
2
Angkor Hospital for Children
Siem Reap, Krong Siem Reap, Cambodia
3
Rumah Sakit Umum Daerah Wates
Yogyakarta, DI Yogyakarta, Indonesia
4
Laos-Oxford-Mahosot Wellcome Trust Research Unit
Vientiane, Laos