Status:
ACTIVE_NOT_RECRUITING
Prospective Natural History Study of Retinitis Pigmentosa
Lead Sponsor:
SparingVision
Conditions:
Retinitis Pigmentosa
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is natural history study of rods and cones degenerations in patients with Retinitis Pigmentosa (RP) caused by pathogenic mutations in RHO, PDE6a or PDE6b gene mutations.
Detailed Description
This is an open, longitudinal, prospective, multicentric study to describe the disease progression in patients with retinitis pigmentosa due to mutation in genes with selective expression in rods: rho...
Eligibility Criteria
Inclusion
- RP with mutations affecting the RHO, PDE6A and PDE6B genes
- Visual acuity ≥ 20/200 for at least one eye at inclusion visit
- Binocular Visual field diameter ≥ 5° as measured on the Goldmann III-4e isopter at inclusion visit
- Patients having signed the informed consent form
- Sufficient knowledge of the local language to ensure understanding of the tasks to be performed and the instructions received
- Patient affiliated to a Health Security System if they are included in a clinical site based in France (per law)
Exclusion
- Patients with any other gene mutation known to be involved in RP
- Patients with other ocular disorder likely to impact the retinal function
- Pregnant or breastfeeding women
Key Trial Info
Start Date :
February 12 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2026
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT04285398
Start Date
February 12 2020
End Date
June 30 2026
Last Update
May 22 2025
Active Locations (2)
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1
UPMC Eye Center
Pittsburgh, Pennsylvania, United States, 15213
2
CHNO XV-XX Paris - CIC 1423
Paris, France, 75012