Status:
COMPLETED
Physiological Changes Induced Through MEP Conditioning in People With SCI
Lead Sponsor:
Medical University of South Carolina
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Spinal Cord Injuries
Neurological Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place i...
Eligibility Criteria
Inclusion
- Neurologically stable (\>1 year post SCI)
- Medical clearance to participate
- Ability to ambulate at least 10 m with or without an assistive device (except for parallel bars)
- Signs of weak ankle dorsiflexion at least unilaterally
- Expectation that current medication will be maintained without change for at least 3 months; stable use of anti-spasticity medication is accepted
Exclusion
- motoneuron injury
- known cardiac condition (e.g., history of myocardial infarction, congestive heart failure, pacemaker use)
- medically unstable condition
- cognitive impairment
- history of epileptic seizures
- metal implants in the cranium
- implanted biomedical device in or above the ches (e.g., a cardiac pacemaker, cochlear implant)
- no measurable MEP elicited
- unable to produce any voluntary TA EMG activity
- extensive use of functional electrical stimulation to the leg on a daily basis
- pregnancy (due to changes in weight and posture and potential medical instability)
Key Trial Info
Start Date :
February 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2025
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT04286191
Start Date
February 22 2021
End Date
November 30 2025
Last Update
December 9 2025
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425