Status:
UNKNOWN
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Conditions:
Hyperactivity
Allergic Rhinitis Due to House Dust Mite
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial ...
Detailed Description
Patients with perennial allergic rhinitis, chronic rhinosinusitis with nasal polyps and healthy control subjects will be recruited. At baseline, nasal secretions and mucosal biopsies will be collected...
Eligibility Criteria
Inclusion
- 18-65 years
- positive skin prick test for house dust mite (for allergic rhinitis group), presence of nasal polyps (for chronic rhinosinusitis with nasal polyps group)
- VAS-score \>5 for rhino(sinus)itis symptoms
Exclusion
- positive skin prick test (for chronic rhinosinusitis with nasal polyps group and healthy control group), presence of nasal polyps (for allergic rhinitis group and healthy control group)
- Acute rhinitis in the past 2 weeks
- (History of) immunotherapy for house dust mite
- Relevant anatomic abnormalities
- Participation in another clinical trial at the moment of this study.
- Use of anticoagulants (apart from acetylsalicylic acid)
- Use of tricyclic antidepressants
- History of intranasal drug usage in the past 12 months
- Pregnancy or breastfeeding
- Malignancy or severe comorbidity
Key Trial Info
Start Date :
January 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT04286542
Start Date
January 20 2020
End Date
December 1 2022
Last Update
May 25 2022
Active Locations (1)
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1
KULeuven
Leuven, Belgium, 3000