Status:
UNKNOWN
Population at Risk of Malignant Hyperthermia: Ambispective Cohort.
Lead Sponsor:
Instituto de Investigación Hospital Universitario La Paz
Collaborating Sponsors:
Universidad Autonoma de Madrid
Conditions:
Hyperthermia, Malignant
Eligibility:
All Genders
Brief Summary
Malignant hyperthermia (MH) is a pharmacogenetic disease that manifests itself as a hypermetabolic response of skeletal musculature, in genetically susceptible patients, with the inhalation of volatil...
Detailed Description
Malignant hyperthermia (MH) is a pharmacogenetic disease that manifests itself as a hypermetabolic response of skeletal musculature, in genetically susceptible patients, with the inhalation of volatil...
Eligibility Criteria
Inclusion
- Patients who have suffered at least one episode of rhabdomyolysis due to related causes in the literature with susceptibility to HM.
- Patients who have been given information about the study and have agreed to sign the consent of the study. The muscle biopsy will be performed under usual clinical practice.
Exclusion
- Patients who have suffered episodes of rhabdomyolysis due to alternative causes: trauma, compression hypoxia during immobilization or loss of consciousness or infectious arterial occlusion (influenza A and B, coxackievirus, Epstein-Barr, HIV, legionella, Streptococcus pyogenes Staphilococcus aureus, clostridium), metabolic or electrolyte abnormalities (hypokalemia, hypophosphatemia, hypocalcemia, non-ketosic hyperosmolar conditions, diabetic ketoacidosis), others.
- Children under 10 years or less than 30 kg are excluded for the in vitro test (muscle biopsy).
Key Trial Info
Start Date :
February 26 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 28 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04287556
Start Date
February 26 2020
End Date
February 28 2025
Last Update
January 13 2022
Active Locations (1)
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1
Hospital Universitario La Paz
Madrid, Spain, 28046