Status:
COMPLETED
Safety and Efficacy Study of VIS649 for IgA Nephropathy
Lead Sponsor:
Visterra, Inc.
Conditions:
Immunoglobulin A Nephropathy
Glomerular Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of VIS649 in participants with immunoglobulin A (IgA) Nephropathy (IgAN)
Detailed Description
This is a Phase 2, double-blind, randomized, placebo-controlled study in patients aged 18 years and above with biopsy confirmed diagnosis of IgAN. The study is designed to test the safety and effectiv...
Eligibility Criteria
Inclusion
- Participants are eligible to be included in the study only if all of the following criteria apply:
- Participant is a male or female ≥ 18 years of age at the time of signing the informed consent.
- Participant must have biopsy-confirmed IgAN.
- Participant has medical records showing they have been on stable and maximally tolerated doses of either ACEI or ARB, as per local SOC and applicable guidelines, for at least 3 months preceding screening. Participants should optimally be on at least 50% of the maximum recommended dose of these agents; however, if a participant is on their maximally tolerated dose (and this is \< 50% of the maximum recommended dose) and has been on this dose for at least 3 months, they may be enrolled. Participants who are unable to tolerate ACEI/ARB therapy may be eligible for participation in the study if their overall management of IgAN, including BP control, is as per local SOC and applicable guidelines.
- Participants must have screening uPCR ≥ 0.75 g/g measured from a 24-hour urine or 24-hour urine protein ≥ 1.0 g/d, as measured from 24-hour urine collection. The proteinuria should be assessed when the participant is considered to be in a steady state with no recent heavy exercise, fever, or other potential issues that could impact the result.
- Participants must have eGFR ≥ 45 mL/min/1.73 m² using the CKD-EPI formula.
- Participant's serum Ig values must meet specified criteria
- Female participants of childbearing potential must have a negative serum pregnancy test prior to the first dose.
- Participant is willing to adhere to contraceptive requirements.
- Participant or a legally authorized representative is able and is willing to give voluntary written informed consent
Exclusion
- Participants are excluded from the study if they meet any of the following criteria:
- Participant has secondary forms of IgAN as defined by the treating physician.
- Participant has co-existing CKD, other than IgAN.
- Participant has evidence of additional pathological findings in the kidney biopsy (eg, diabetic kidney disease, membranous nephropathy, or lupus nephritis). However, hypertensive vascular changes are acceptable.
- Participant has kidney biopsy MEST or MEST-C score as defined in the protocol.
- Participant has nephrotic syndrome.
- Participant has received a solid organ transplant, including kidney.
- Participant has received bone marrow or hematologic stem cell transplantation.
- Participant is currently receiving systemic immunosuppression (excluding topical, ophthalmic, per rectum, or inhaled corticosteroids).
- Participant has received treatment with systemic corticosteroid therapy within 16 weeks of initial screening.
- Participant has received treatment with a systemic immunosuppressive agents within 16 weeks of initial screening.
- Participant has any chronic infectious disease.
- Participant has acute infectious disease at the time of screening.
- Participant has Type 1 diabetes.
- Participant has uncontrolled Type 2 diabetes, as evidenced by a screening hemoglobin A1c value \> 8%.
- Participant has uncontrolled BP (\> 140 mm Hg systolic or \> 90 mm Hg diastolic)
- Participant has a history of chronic autoimmune neurodegenerative disorder such as multiple sclerosis.
- Participant has a known allergy or intolerance to any component of the study intervention.
- Participant is breastfeeding.
- Participant has poorly compensated or controlled ischemic heart disease or cardiomyopathy, as judged by the Investigator.
- Participant has chronic obstructive pulmonary disease (COPD) or asthma that has required systemic steroid therapy during the prior year.
- Participant has known cirrhosis or liver dysfunction, defined as presence of coagulopathy, platelet count \< 100,000/μL or alanine aminotransferase \> 3× upper limit of normal.
- Participant has active malignancy or is receiving chemotherapy for malignancy, except for nonmelanoma skin cancers and cervical carcinoma in situ. Participants with prior malignancy who have been documented to be cancer-free for ≥ 5 years may be enrolled.
- Participant is planning or scheduled to undergo a tonsillectomy. Prior tonsillectomy is acceptable (if greater than 6 months prior to screening).
- Participant enrolled in another investigational drug or device study within 3 months prior to initial screening.
- Participant with a pre-existing illness other than those listed above that, in the opinion of the Investigator, would place the participant at increased risk through participation in this study.
- Participant is unable to comply with study protocol procedures and/or study visit schedules.
- Participant with known or suspected alcohol or drug abuse that would compromise their safety or study participation of the participant, in the opinion of the Investigator.
Key Trial Info
Start Date :
July 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 18 2023
Estimated Enrollment :
155 Patients enrolled
Trial Details
Trial ID
NCT04287985
Start Date
July 20 2020
End Date
June 18 2023
Last Update
November 21 2024
Active Locations (93)
Enter a location and click search to find clinical trials sorted by distance.
1
Visterra Investigational Site
Birmingham, Alabama, United States, 35294
2
Visterra Investigational Site
Los Angeles, California, United States, 90027-5969
3
Visterra Investigational Site
Oxnard, California, United States, 93036
4
Visterra Investigational Site
Palo Alto, California, United States, 94305