Status:
UNKNOWN
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia
Lead Sponsor:
Assiut University
Conditions:
Pre-Eclampsia
Eligibility:
FEMALE
20-40 years
Brief Summary
1. To measure the level of expression of MXRA5 and ANXA4 genes in preeclampsia (PE). 2. To detect the effect of heavy metals (lead (Pb) and arsenic (AR)) on these two genes in the pathology of PE. 3. ...
Detailed Description
* Preeclampsia (PE) is a diverse multisystem syndrome defined as a new onset of hypertension along with evidence of significant multiorgan dysfunction in previously normotensive women 20 weeks of gest...
Eligibility Criteria
Inclusion
- Gestational age is \>28 weeks.
- Clinically diagnosed PE with blood pressure (≥140/90 mmHg) and proteinuria (≥300mg/dl).
- Healthy pregnant women (age matched control group).
Exclusion
- Gestational diabetes.
- Pregestational hypertension (essential hypertension) or proteinuria.
- Systemic illness.
- Vaginal infection.
- Major known fetal or chromosomal anomalies.
- Multiple gestations.
- Intrauterine infections.
- Preterm premature rupture of membranes.
- Sepsis.
- Fever.
- Colitis ulcerosa.
- Crohn's disease.
- Chronic renal disease.
- Rheumatic disease.
Key Trial Info
Start Date :
April 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04287998
Start Date
April 1 2020
End Date
May 1 2021
Last Update
February 27 2020
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