Status:
COMPLETED
Use of Ziv Aflibercept in Different Retinal Diseases
Lead Sponsor:
Amin El Sayed Nawar
Collaborating Sponsors:
Tanta University
Conditions:
Central Retinal Vein Occlusion With Macular Edema
Eligibility:
All Genders
31-63 years
Phase:
PHASE1
PHASE2
Brief Summary
A prospective interventional case series study was conducted on 20 eyes of 20 patients with active myopic choroidal neovascularisation (CNV) ,20 eyes with resistant diabetic macular edema and 15 eyes ...
Detailed Description
Intravitreal injection of 1.25 mg of ziv aflibercept was done in different retinal diseases including myopic CVN,resistant diabetic macular edema to previous ranibizumab injection and non ischaemic CR...
Eligibility Criteria
Inclusion
- The study included treatment naive patients suffering from recently diagnosed active myopic subfoveal or juxtafoveal CNV less than 2 months documented by fundus fluorescein angiography (FFA)and optical coherence tomography (OCT ) , pathological myopia more than 6 D was included .
Exclusion
- Previous intraocular surgery .
- Coincident retinal pathology as diabetic retinopathy, retinal vein occlusion .
- CNV due to other causes like age related macular degeneration ,angioid streaks,trauma and choroiditis.
- Extrafoveal myopic CNV .
- Patients received other lines of treatment for CNV like photodynamic therapy ,laser photocoagulation or intravitreal injection of triamcinolone or other anti VEGF(vascular endothelial growth factor) agents.
- Known glaucoma , clinical suspicion of glaucoma or IOP(intraocular pressure) more than 20 mmHg.
- Prior ocular inflammation.
- The presence of retinal degeneration.
- Patients who didnot complete 6 months of follow up
Key Trial Info
Start Date :
June 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT04290195
Start Date
June 1 2019
End Date
January 1 2020
Last Update
October 11 2021
Active Locations (1)
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1
Tanta University
Tanta, El Gharbia, Egypt, 31111