Status:
UNKNOWN
Brain Ultrasound With Contrast Microbubbles Injection in Shock Status
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Shock
Microcirculation
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Alterations in the brain microcirculation may be involved in patients with shock. For a three-day period, we investigate the brain microcirculation using contrast-enhanced ultrasound with microbubble ...
Detailed Description
Non-invasive brain ultrasound with transcranial echo-color doppler (IE 33, Philips Medical System, the Netherlands) is performed in three steps to 1) evaluate the global cerebral blood volume, 2) to e...
Eligibility Criteria
Inclusion
- Septic shock criteria: refractory arterial hypotension or hypoperfusion abnormalities after fluid resuscitation with serum lactate \> 4mmmol/dl, oliguria and mental status alteration or delirium.
- Cardiogenic shock is defined as refractory shock associated with oliguria and mental status alteration following acute myocardial infarction or post-cardiac surgery.
Exclusion
- Younger than 18 years old
- Pregnancy
- Diabetes
- Acute or chronic neurological disorder: epileptics, stroke, bleeding, trauma, post-neurosurgery, post- cardiac arrest, tumor, meningitis.
- Severe dementia, psychiatric or neuromuscular disability
- Acute coronary syndrome within one previous week
- Respiratory distress ARDS with arterial oxygenation less than 70mm Hg or the FiO2 / PaO2 ratio \< 200
- Advanced liver cirrhosis
- Terminal renal failure with hemodialysis and high serum uremia.\> 200.
- Drug intoxications. Alcohol withdrawal.
- Advanced malign diseases
- Allergy to the microbubble contrast product Sonovue ®
- Insufficient echogenicity of bilateral temporal window to ultrasound and incomplete insonation of the intracerebral arteries
- Significant intracerebral and extracerebral arteries stenosis or severe atheromatous calcifications.
- Vertebral artery hypoplasia.
Key Trial Info
Start Date :
March 6 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04290767
Start Date
March 6 2019
End Date
December 31 2022
Last Update
March 2 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Universitair Ziekenhuis Brussel
Brussels, Belgium, 1090