Status:
WITHDRAWN
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection
Lead Sponsor:
Xijing Hospital
Collaborating Sponsors:
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Conditions:
Coronavirus Infections
Pneumonia, Viral
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (COVID-19) originated in China in December 2019. At present, there are no pro...
Detailed Description
To date, no targeted therapeutic treatments for the ongoing COVID-19 outbreak have been identified. Antiviral combined with adjuvant therapies are currently under investigation. The clinical spectrum ...
Eligibility Criteria
Inclusion
- Laboratory confirmed COVID19 infection defined with a positive RT-PCR from any specimen.
- Hospital admission with at least one of the following:
- fever ≥ 36.6 °C from axillary site; or ≥ 37.2°C from oral site; or ≥ 37.6°C from tympanic or rectal site.
- Respiratory rate ≥ 24 bpm
- cough
- Spontaneous breathing with or without hypoxia of any degree. Gas exchange and ventilation maybe assisted by any continuous continuous airway pressure (CPAP), or any system of Non Invasive Ventilation (NIV), with Positive End-Expiratory Pressure (PEEP) ≤ 10 cmH2O.
- ≤ 8 days since onset of the symptoms
Exclusion
- Pregnancy, or positive pregnancy test in a predose examination
- Open tracheostomy
- Therapy with high flow nasal cannula
- Clinical controindication, as deemed by the attending physician
Key Trial Info
Start Date :
March 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04290858
Start Date
March 1 2020
End Date
February 1 2022
Last Update
March 24 2020
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