Status:
UNKNOWN
The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)
Lead Sponsor:
Sunnybrook Health Sciences Centre
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Acute Brain Injury
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
This trial in brain-injured patients will test which of the following will lead to better patient outcomes: (1) an airway management pathway consisting of daily assessments and removal of the breathin...
Detailed Description
Thousands of patients suffer severe brain injuries every year, from causes such as trauma, stroke, and infection. These patients are usually not fully awake and need help with their breathing and with...
Eligibility Criteria
Inclusion
- Age \> 16 years
- Acute brain injury (subarachnoid hemorrhage, diffuse axonal injury, ischemic stroke, intracerebral hemorrhage, brain tumor, global cerebral anoxia/cardiac arrest, meningitis/encephalitis, cerebral abscess, epidural hematoma, subdural hematoma, seizure) that occurred within the previous 4 weeks
- Receiving mechanical ventilation via endotracheal tube for ≥ 48 hours
Exclusion
- Quadriplegic
- Neuromuscular disease that will result in prolong need for mechanical ventilation, including but not limited to Guillain-Barre syndrome, cervical spinal cord injury, advanced multiple sclerosis
- Do-Not-Reintubate order in place
- Previously randomized in this trial
- Underlying pre-existing condition with life expectancy less than 6-months
- Current enrolment in an RCT that precludes NEURO-ETT co-enrollment
Key Trial Info
Start Date :
April 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2023
Estimated Enrollment :
332 Patients enrolled
Trial Details
Trial ID
NCT04291235
Start Date
April 1 2020
End Date
January 1 2023
Last Update
March 2 2020
Active Locations (14)
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1
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
2
Royal Columbian Hospital
New Westminster, British Columbia, Canada, V3L 3W7
3
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
4
Nova Scotia Health Authority
Halifax, Nova Scotia, Canada, B3H 3A7