Status:
COMPLETED
Evaluation of the Effects of Semen Incubation With ANDROSITOL®DGN on Sperm Motility and Mitochondrial Membrane Potential
Lead Sponsor:
University of Catania
Conditions:
Asthenozoospermia
Mitochondrial Damage
Eligibility:
MALE
18-50 years
Phase:
NA
Brief Summary
Mitochondria is the cellular organelle responsible for the production of the energy necessary to fuel sperm motility. It has been demonstrated that mitochondrial efficiency is correlated to the fertil...
Detailed Description
Mitochondria is the cellular organelle responsible for the production of the energy necessary to fuel sperm motility. It has been demonstrated that mitochondrial efficiency is correlated to the fertil...
Eligibility Criteria
Inclusion
- /
Exclusion
- \- Absolute asthenozoospermia
- Leukocytospermia
- Positive semen culture and/or urethral swab
- Human Papilloma Virus (HPV) DNA in semen
- History of cryptorchidism
- 3rd degree varicocele
- Markedly reduced testicular volume
- Decompensated diabetes mellitus and other systemic diseases leading to oxidative stress (e.g. chronic renal failure, liver failure)
- Altered concentrations of the following hormones: luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, prolactin, 17β-estradiol
- Alcohol and drug abuse
- Heavy cigarette smoke (≥10 cigarettes/day)
- Body Mass Index (BMI) \>35 kg/m2
Key Trial Info
Start Date :
October 23 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 31 2020
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04291495
Start Date
October 23 2018
End Date
October 31 2020
Last Update
May 13 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Clinical and Experimental Medicine, University of Catania
Catania, Italy, 95123