Status:
COMPLETED
Back-to-back Endoscopy Versus Single-pass Endoscopy and Chromoendoscopy in IBD Surveillance
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
UMC Utrecht
Leiden University Medical Center
Conditions:
Inflammatory Bowel Diseases
Colorectal Neoplasms
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The current international guidelines for CRC surveillance in IBD recommend as first choice the use of chromoendoscopy, and as an alternative high-definition white light endoscopy (HDWLE) for optimal d...
Detailed Description
The investigators assume based on previous research a yield of 12% using high-definition white light endoscopy and 24% using either chromoendoscopy or high-definition white light endoscopy with a seco...
Eligibility Criteria
Inclusion
- Signed informed consent
- Patients with inflammatory bowel disease, an estimated involvement of at least 30% of the colonic surface and a disease duration of at least 8 years (or any disease duration in case of concomitant primary sclerosing cholangitis).
- Previous assessable surveillance endoscopy \> 1 year
- Age \> 18 years
Exclusion
- Active colitis \> 20 cm and/or inflammation resulting in an insufficient surveillance procedure according to the endoscopist.
- Allergy or intolerance to methylene blue
- Insufficient bowel cleansing (BBPS \<6)
- Refusing or incapable to agree with informed consent
- Pregnant women
- \> 50 % of the colon surgically removed
Key Trial Info
Start Date :
March 13 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 7 2023
Estimated Enrollment :
563 Patients enrolled
Trial Details
Trial ID
NCT04291976
Start Date
March 13 2020
End Date
November 7 2023
Last Update
November 21 2023
Active Locations (4)
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1
Radboudumc
Nijmegen, Gelderland, Netherlands, 6525GA
2
Utrecht University Medical Center
Utrecht, Gelderland, Netherlands, 3584CX
3
Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands, 1105 AZ
4
Leiden University Medical Center
Leiden, South Holland, Netherlands