Status:
COMPLETED
Deficit-specific Training in Spinal Disorders
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Swiss National Science Foundation
Conditions:
Spinal Cord Injuries
Multiple Sclerosis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Impairments of walking function after spinal cord lesion due to, for example, inflammation, ischemia or trauma are exceptionally diverse. Depending on the size, location and completeness of the spinal...
Eligibility Criteria
Inclusion
- Age 18-80 years
- Diagnosis of chronic spinal cord injury (\>6 months cervical or thoracic motor incomplete traumatic or non-traumatic (AIS C, D) above T12 or diagnosis of either primary- progressive, secondary-progressive, or relapsing-remitting multiple sclerosis as defined by the revised McDonald criteria for at least 3 months and with at least one spinal cord lesion as verified in clinical MRI images
- Able to walk without assistance or devices on the treadmill and 10m over ground, but must have impaired walking function as demonstrated by neurological examination.
Exclusion
- Women who are pregnant or breast feeding
- Current orthopaedic problems of lower limbs
- History of major cardiac condition (e.g., infarction, insufficiency (NYHA II-IV))
- History of major pulmonary condition (e.g., chronic obstructive pulmonary disease GOLD II-IV)
- Current major depression or psychosis
- MS exacerbation within 3 months prior to the screening or at any time during the screening period
- Participation in another training study
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 19 2025
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT04292717
Start Date
January 1 2021
End Date
November 19 2025
Last Update
December 2 2025
Active Locations (1)
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1
Universitätsklinik Balgrist
Zurich, Switzerland, 8008