Status:
COMPLETED
Fuel Utilization, Diet Composition, and Exercise in African American Women
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Conditions:
Obesity
Diabetes
Eligibility:
FEMALE
20-40 years
Phase:
NA
Brief Summary
African American women have a high prevalence of obesity and type 2 diabetes and do not optimally burn fat and carbohydrates in response to changes in these nutrients in their diets. This research pro...
Detailed Description
African Americans have the highest age-adjusted death rate for heart disease and diabetes in the United States. Obesity, a significant risk factor for these conditions, is highly prevalent in African ...
Eligibility Criteria
Inclusion
- African American descent and all four grandparents reported as African Americans
- DNA will also be collected so admixture could be measured post study
- Reported good health (blood work, Hx and PE)
- Non-diabetic (OGTT)
- Pre-menopausal, Age range 20-40 years BMI range of 25-40, with regular menstrual periods
- Sedentary (exercise no more than 2 times/week, for one hour or spend no more than 1000 - 1500 Kcal/wk in physical activity as determined by a Paffenbarger questionnaire).
Exclusion
- Any cardiac or pulmonary illnesses which may interfere with their capacity to exercise
- Active smoker
- Consume more than 2 oz. of ethanol/day
- Weight change greater than + 2 kg in the past 3 months
- Currently taking medications or have any physical conditions which may affect insulin action and/or lipid metabolism or have hyperlipidemia (plasma triglyceride greater than or equal to 350 mg/dl or total cholesterol levels greater than or equal to 300 mg/dl).
- Metal implants (ex: pacemaker, implanted jewelry, etc)
- 1st degree family history of type diabetes 2 diabetes (Will be noted but will not constitute an exclusionary criteria).
- The subjects' usual diets will be evaluated by the Block 98.2 Food Frequency Questionnaire (BDDS, Berkeley, CA).
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 20 2013
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT04293367
Start Date
June 1 2009
End Date
November 20 2013
Last Update
March 3 2020
Active Locations (1)
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1
Mount Sinai St. Luke's Clinical Research Unit
New York, New York, United States, 10025