Status:
UNKNOWN
Enhanced-contrast Brain Ultrasound in Cardiorespiratory Arrest
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Cardiorespiratory Arrest
Microcirculation
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Brain microcirculation alterations may be involved in comatose patients and non-survivors after cardiorespiratory arrest. For a three day-period, we investigate brain microcirculation using contrast-e...
Detailed Description
Brain ultrasound, extracranial echo-color duplex and ocular ultrasound (IE 33, Philips Medical System, the Netherlands) are performed in the first 24 hours, at 48 hours, and at 72-96 hours after succe...
Eligibility Criteria
Inclusion
- ICU patients with successful resuscitation after out-hospital or in-hospital cardiorespiratory arrest
Exclusion
- Younger than 18 years old
- Pregnancy
- Acute or history of neurological disorder: stroke, bleeding, trauma, post-neurosurgery, tumor, meningitis.
- Severe dementia, psychiatric or neuromuscular disability
- Untreated Acute coronary syndrome
- Acute Respiratory Distress Syndrome (ARDS) with the ratio of arterial oxygen partial pressure (mmHg) to fractional inspired oxygen (PaO2/ FiO2) less than 150
- Severe systolic pulmonary hypertension above 90 mmHg
- Advanced liver cirrhosis with hyperammonemia
- Uremia \> 200mmol/L
- Acute drug intoxications with coma
- Acute alcohol intoxication or withdrawal syndrome.
- Advanced malign diseases.
- History of allergy to the microbubble contrast SONOVUE.
- Insufficient echogenicity to ultrasound and incomplete insonation of the intracerebral arteries and brain parenchyma.
- Significant intracerebral and extracerebral arteries stenosis (≥ 70%) or vertebral artery hypoplasia (3mm).
Key Trial Info
Start Date :
November 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04294316
Start Date
November 1 2019
End Date
December 31 2022
Last Update
May 19 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Universitair ziekenhuis Brussel
Brussels, Belgium, 1200