Status:
TERMINATED
Treatment of Post-Chemo Cognitive Impairment w/Transcranial Magnetic Stimulation (Chemobrain TMS)
Lead Sponsor:
University of Arizona
Conditions:
Chemo-brain
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this pilot study, the investigators propose to test the efficacy of rTMS for the treatment of PCCI. Efficacy measures will include baseline and post-rTMS neuropsychological testing, functional MRI ...
Detailed Description
Transcranial magnetic stimulation (TMS) is a safe and non-invasive brain stimulation technique. It uses a magnetic coil to stimulate brain tissue painlessly using only a magnet (no electrodes or elect...
Eligibility Criteria
Inclusion
- Adult (\>=18).
- PCCI diagnosis (see information below).
- Right Handed (We will not enroll left-handed dominant people because they tend to have more symmetric brain function and thus targeting the left frontal region may not be as effective.)
- English speaking.
- Cancer treatment completed and considered curative with the exception of endocrine therapy after chemotherapy.
- Able to attend daily intervention (Monday-Friday) for 2 weeks.
- Not enrolled in another interventional study within 6 months prior to beginning this study.
Exclusion
- Pregnancy or thinking of becoming pregnant.
- Undergoing active treatment for cancer.
- Routine contraindications for MRI (including incompatible medical implants or metal fragments in the body at risk for migration or heating with application of the magnetic field) including severe claustrophobia.
- History of brain metastasis or other brain tumor.
- History of stroke or traumatic brain injury.
- Frequent or severe headaches.
- Cognitive or mood disorder prior to chemotherapy (i.e. dementia or depression).
- History of epilepsy, or other seizure disorders.
- History mental health disorders, such as substance misuse, bipolar disorder or psychosis.
- Taking medication for seizures or that could lower seizure threshold if withdrawn.
- Inability to complete neuropsychological testing.
- Prior treatment with rTMS. We will enroll subjects without prior experience with rTMS.
Key Trial Info
Start Date :
March 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2022
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT04295720
Start Date
March 5 2021
End Date
March 30 2022
Last Update
March 3 2023
Active Locations (1)
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1
University of Arizona Cancer Center
Tucson, Arizona, United States, 85724