Status:
RECRUITING
Brain Health in Breast Cancer Survivors
Lead Sponsor:
Jonsson Comprehensive Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Cognitive Impairment
Cognitive Function
Eligibility:
FEMALE
35-65 years
Brief Summary
Endocrine therapy (ET) is widely used to treat hormone receptor positive breast cancer and prevent recurrence by downregulating estrogen function. However, ETs readily cross the blood brain barrier an...
Detailed Description
Endocrine therapy (ET) is widely used to treat hormone receptor positive breast cancer and prevent recurrence by downregulating estrogen function. However, ETs readily cross the blood brain barrier an...
Eligibility Criteria
Inclusion
- Age 35-65
- Fluent in English
- Adequate vision/hearing to complete testing
Exclusion
- History of major or mild neurocognitive disorder or dementia
- Diagnosis of major neurological condition (e.g., epilepsy, Parkinson's Disease, stroke)
- Diagnosis of a major psychiatric disorder (e.g., bipolar disorder, schizophrenia)
- Untreated/unstable unipolar depression or anxiety
- Prior history of cancer or chemotherapy (for controls, any history)
- History of a learning disorder
- History of head injury with loss of consciousness \>20 minutes
- History of salpingo-oophorectomy or hysterectomy
- A cardiac pacemaker
- Implanted electronic device
- Claustrophobia
- Currently pregnant
- Orbital metal implant or other metallic foreign bodies
- Additional exclusion criteria for controls: current use of a contraceptive agent that interferes with endogenous hormonal fluctuation (e.g., oral contraceptive pill) or precludes determination of menstrual pattern (e.g., hormonally secreting intrauterine device), or current treatment with systemic estrogen replacement therapy.
Key Trial Info
Start Date :
March 11 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 15 2027
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04297020
Start Date
March 11 2020
End Date
March 15 2027
Last Update
May 13 2025
Active Locations (1)
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1
University of California at Los Angeles
Los Angeles, California, United States, 90095