Status:
COMPLETED
Early Detection of Cardiac Impairment and Prediction of RV Hypertrophy in Patients With CTD
Lead Sponsor:
RenJi Hospital
Conditions:
Connective Tissue Diseases
Right Ventricular Hypertrophy
Eligibility:
All Genders
18-80 years
Brief Summary
There have been reports suggesting that progressive RV failure and death in connective tissue disease (CTD) are related to right ventricular hypertrophy (RVH) and dilation, irrespective of pulmonary a...
Detailed Description
Patients with connective tissue disease (CTD) frequently exhibit multi-organ pathophysiological and functional damage. The heart, one of the leading causes of CTD mortality, has attracted increasing a...
Eligibility Criteria
Inclusion
- Inclusion Criteria for CTD with RVH
- Age between 18-80 years old.
- Definite connective tissue diseases diagnosis.
- Echocardiography demonstration (later confirmed by CMR) of a hypertrophic RV when maximal end-diastole RV wall thickness \>4 mm due to CTD
- Inclusion Criteria for CTD without RVH
- Age between 18-80 years old.
- Definite connective tissue diseases diagnosis.
- Echocardiography demonstration (later confirmed by CMR) that maximal end-diastole RV wall thickness ≤4 mm
- Inclusion Criteria for Control group:
- Absence of known systemic diseases
- Normal examinations
- Age between 18-80 years old.
- Providing written informed consent
- Exclusion Criteria:
- Age \<18 years old or \>80 years old
- Documented coronary artery disease or prior angiography for coronary artery disease (\>50% stenosis).
- Patients with known congenital heart disease or other systemic diseases that might induce RVH.
- Patients with standard metallic contraindications to CMR or an estimated glomerular filtration rate \< 30 ml/min/1.73 m2.
Exclusion
Key Trial Info
Start Date :
July 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2016
Estimated Enrollment :
136 Patients enrolled
Trial Details
Trial ID
NCT04297371
Start Date
July 1 2014
End Date
November 1 2016
Last Update
August 13 2020
Active Locations (1)
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1
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127