Status:
COMPLETED
PSMA-PET and MRI for Detection of Recurrent Prostate Cancer After Radical Treatment
Lead Sponsor:
Norwegian University of Science and Technology
Collaborating Sponsors:
Haukeland University Hospital
University Hospital of North Norway
Conditions:
Prostatic Neoplasms
Eligibility:
MALE
18+ years
Brief Summary
Approximately one third of prostate cancer patients experience biochemical relapse following initial radical prostatectomy or curative radiotherapy. To determine further treatment, it is of utmost imp...
Eligibility Criteria
Inclusion
- Inclusion Criteria (surgery cohort):
- Prostate cancer patients with biochemical relapse in accordance with the European Association of Urology (EAU) guidelines on prostate cancer; two consecutive measurements with PSA ≥ 0.2 ng/ml following radical prostatectomy or PSA \> 2.0 ng/ml above the nadir following definitive radiotherapy
- Potential candidates for loco-regional pelvic salvage treatment based on age and co-morbidity
- Exclusion Criteria:
- Previous salvage therapy for recurrent prostate cancer
- General contra-indications for an MRI exam (pacemaker, aneurysm clips, any form of metal in the body, or severe claustrophobia)
- Serious concomitant systemic disorders or reduced cognitive functioning that in the opinion of the investigator would compromise the patient's ability to complete the study or interfere with the evaluation of the efficacy and safety of the study objectives
- Impaired renal function defined as estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73 m2
- Hormonal treatment during the last three months
Exclusion
Key Trial Info
Start Date :
May 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2023
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04298112
Start Date
May 1 2020
End Date
May 1 2023
Last Update
November 15 2024
Active Locations (3)
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1
Haukeland University Hospital
Bergen, Norway
2
University Hospital of North Norway
Tromsø, Norway
3
St Olavs Hospital
Trondheim, Norway