Status:
UNKNOWN
A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty
Lead Sponsor:
Colorado Joint Replacement
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
21-75 years
Phase:
PHASE3
Brief Summary
The primary purpose of this study was to determine if cannabinoid use decreases narcotic consumption in patients undergoing total knee arthroplasty (TKA).
Detailed Description
Subjects enrolled will be randomized into one of two groups either receiving the study drug or a placebo and will be followed for the first 6 weeks with regards to outcomes data.
Eligibility Criteria
Inclusion
- Provision of signed and dated informed consent from
- Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study.
- Male or Female
- Age 21-75
- Unilateral total knee arthroplasty at Colorado Joint Replacement
- All individuals will be screened for drug use (including cannabis) at their preoperative appointment
- Ability to take oral medication and be willing to adhere to the dronabinol regimen
- For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.
- For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner.
Exclusion
- Narcotic use in the past 6 weeks
- Regular cannabis use in the past 3 months
- Major depression or anxiety disorders
- Documented psychiatric illness (e.g. bipolar, schizophrenia)
- Seizure disorder
- Current or previous history of drug and alcohol abuse
- Known allergic reactions to components of dronabinol
- Tobacco use in the past 90 days
- Treatment with another investigational drug
- Patients that cannot receive spinal anesthesia
- Patients that cannot receive the standardized multimodal pain medications (i.e. Tylenol, gabapentin and meloxicam)
- Patients that are not able to go home after leaving the hospital and require a short term rehabilitation facility
Key Trial Info
Start Date :
February 5 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 5 2025
Estimated Enrollment :
460 Patients enrolled
Trial Details
Trial ID
NCT04298528
Start Date
February 5 2020
End Date
February 5 2025
Last Update
January 10 2023
Active Locations (1)
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1
Colorado Joint Replacement
Denver, Colorado, United States, 80210