Status:
UNKNOWN
White Matter Hyperintensities Subtypes in Cerebral Small Vessel Disease : 7 Tesla Ultra-high Resolution Imaging MRI
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Cerebral Small Vessel Diseases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cerebral small vessel diseases (SVD) are a very frequent group of disorders all characterized by alterations of the structure and/or function of small arteries, veins and capillaries. In these disorde...
Eligibility Criteria
Inclusion
- Subjects or patients with MRI defined cerebral small vessel disease including different extents of white matter hyperintensities, presumably related to hypertension (30 patients), cerebral amyloid angiopathy (30 patients), CADASIL (30 patients) or any other monogenic form of cerebral small vessel disease (HTRA1 AD, COLIVA1… 10 patients)
- Age ≥ 18 years
- No dementia (MMSE \> 24 and absence of dependence in daily activities)
- No disability (modified Rankin's scale \< 2)
- No history of severe allergic reaction, in particular to gadolinium infusion
- No history of severe asthma
- No renal insufficiency (clearance \< 60 ml/mn/1.73 m2)
Exclusion
- Contraindications to MRI
- Standard MRI of bad quality due to movement artefacts
- Dementia or disability
- Patient without affiliation to the French social security
Key Trial Info
Start Date :
March 4 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 4 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04298866
Start Date
March 4 2021
End Date
June 4 2023
Last Update
May 4 2021
Active Locations (1)
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1
Hopital Lariboisière
Paris, France, 75010