Status:
COMPLETED
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
Lead Sponsor:
University of Kansas Medical Center
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Healthy Aging
Alzheimer Disease
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD). The study team will also examine lactate metabolism, re...
Detailed Description
Aim 1: Compare the effects of acute, moderate intensity and acute, higher intensity exercise on cerebral glucose metabolism in nondemented (ND) elderly and AD subjects. ND (n=30) and AD (n=30) subject...
Eligibility Criteria
Inclusion
- Age 60 and older
- Stable medication doses (\>1month)
- Post-menopausal
- Diagnosis of either Nondemented (CDR 0) or Probable AD (CDR 0.5 or 1 only)
Exclusion
- Inability to provide consent
- Diagnosis of insulin-dependent (Type 1) Diabetes Mellitus
- Recent ischemic heart disease (\<2 years)
- Diagnosis of an clinically significant chronic disease including cardiovascular disease (CVD), other metabolic diseases (e.g., thyroid), cancer, human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome
- Excluded from or unable to complete an MRI scan
- Any Neurological disorders that have the potential to impair cognition or brain metabolism (e.g., Parkinson's disease, stroke defined as a clinical episode with neuroimaging evidence in an appropriate area to explain the symptoms).
- Clinically significant depressive symptoms that may impair cognition, abnormalities in B12, rapid plasma regain (RPR), or thyroid function that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment
Key Trial Info
Start Date :
August 28 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 31 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04299308
Start Date
August 28 2020
End Date
October 31 2023
Last Update
July 23 2025
Active Locations (1)
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1
Univeristy of Kansas Medical Center
Kansas City, Kansas, United States, 66160