Status:
COMPLETED
Muscle in Obesity: Imaging, Function and microRNA
Lead Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Collaborating Sponsors:
University of Sheffield
University of Liverpool
Conditions:
Muscle Function
Eligibility:
FEMALE
60-80 years
Brief Summary
Growing evidence suggests that dynapenic abdominal obesity is associated with a greater risk of falls, functional disability and hospitalisation compared to those with dynapenia, obesity or neither ph...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Caucasian
- Female
- BMI 18.5-25 or 30-40kg/m2
- Ages 60-80 years
- Sufficiently mobile to undergo scanning and biomechanical testing
- Able to remain motionless during scans
- Able and willing to participate in the study and provide written informed consent
- Exclusion Criteria:
- BMI 18.5-25kg/m2 AND waist circumference \>88cm i.e. normal weight AND abdominally obese
- BMI 30-40kg/m2 AND waist circumference \<88cm i.e. obese AND not abdominally obese
- History of any long-term immobilisation (duration greater than 2 weeks in the past 12 months)
- History of hospital admission in the past 3 months
- History of recent significant weight loss (5% in 3 months or 10% in 6 months)
- Diabetes mellitus
- History of current conditions which may affect muscle metabolism
- Malabsorption syndromes e.g. inflammatory bowel disease, pancreatic insufficiency etc.
- Chronic renal disease
- Diagnosed eating disorder
- Conditions which prevent the undertaking or analysis of the MRI and DXA scans or the interpretation of their results e.g. hip prosthesis, metal implants etc.
- Conditions which prevent the undertaking of the fatigue protocols e.g. hypertension etc.
- Use of medications or treatment known to affect muscle metabolism
- o Anabolic steroids, glucocorticoids, antiretrovirals etc.
- Excessive alcohol intake defined as greater than 21 units per week
- Competitive athlete, defined as participating in competitive sport at amateur or professional level
- Conditions which prevent the undertaking of a 6-minute walking test e.g. unstable angina or myocardial infarction during the previous month.
Exclusion
Key Trial Info
Start Date :
September 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 17 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04300504
Start Date
September 1 2021
End Date
March 17 2023
Last Update
November 18 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Sheffield/Sheffield Teaching Hospitals
Sheffield, South Yorkshire, United Kingdom