Status:
RECRUITING
Study of CAR-T Therapy in Older Patients
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
Lymphoma
Refractory B-Cell Lymphoma
Eligibility:
All Genders
60+ years
Brief Summary
This study is being done to find out how older patients respond to CAR-T cell therapy and how the treatment affects their quality of life. This is a quality of life study and participating in the stud...
Eligibility Criteria
Inclusion
- are ≥60 years old (all cohorts)
- have pathologically confirmed, relapsed refractory lymphoid malignancy or plasma cell disorder receiving a commercial CAR T-cell product (all cohorts)
- able to speak and understand English (cohort 1 and 4 only)
- have a MoCA score of less than 26 out of 30 during the GA visit by a geriatrician prior to CAR T-cell treatment (cohort 4 only)
Exclusion
- Any prior commercial or investigational CAR T therapy (all cohorts)
- Current diagnosis of major Axis I psychiatric disorder (DSM-IV), major depression, bipolar disorder, or schizophrenia, as per medical records or patient report (cohort 1 only)
- History of a neurological disorder, neurodegenerative disease, or traumatic brain injury with loss of consciousness (\>60 minutes), as per medical records or patient report (cohort 1 only)
- Current ongoing substance abuse and/or history of substance abuse, as per medical records or patient report (cohort 1 only)
- History of CNS disease (cohort 4 only)
Key Trial Info
Start Date :
March 4 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 4 2026
Estimated Enrollment :
154 Patients enrolled
Trial Details
Trial ID
NCT04300998
Start Date
March 4 2020
End Date
March 4 2026
Last Update
June 13 2025
Active Locations (1)
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1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065