Status:
UNKNOWN
Oral Versus Intravenous Antibiotics for the Treatment of Pleural Space Infection: a Randomized Controlled Pilot Trial
Lead Sponsor:
St. Joseph's Healthcare Hamilton
Collaborating Sponsors:
Vaibhav Mokashi
Conditions:
Pleural Infection
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
We aim to conduct a pilot trial assessing oral versus intravenous therapy for pleural space infections.
Detailed Description
Pleural space infections are a frequent clinical problem resulting in significant morbidity and mortality as well as healthcare cost. Despite the increasing burden of disease, there are no clinical tr...
Eligibility Criteria
Inclusion
- Must meet our study definition of pleural space infection
- Age \> or = 18 years old
- Life expectancy \> 1 year
- Received intravenous or oral antibiotics for = or \< 7 d from surgical intervention or received a total of = or \< 7 d of antibiotics if no intervention performed
Exclusion
- S. aureus bacteremia or endocarditis in the last 1 month
- Another concomitant infection requiring prolonged IV antibiotics
- Esophageal rupture or malignant pleural effusion
- Septic shock or systemic features requiring IV antibiotics
- Mycobacterial, fungal or parasitic pleural space infection
- No oral antibiotic options available
- Unlikely to comply with therapy
Key Trial Info
Start Date :
May 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04301869
Start Date
May 1 2020
End Date
December 1 2021
Last Update
March 10 2020
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