Status:

COMPLETED

Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression

Lead Sponsor:

University of California, San Francisco

Conditions:

Opioid; Intoxication, Perception Disturbance (Acute)

Acute Pain

Eligibility:

All Genders

20-55 years

Phase:

PHASE1

Brief Summary

Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and ...

Detailed Description

Healthy volunteers aged 20-55 will receive a weight-based opioid (remifentanil) infusion for 10 minutes. Vital signs including SpO2, transcutaneous CO2, and respiratory rate will be continuously measu...

Eligibility Criteria

Inclusion

  • Healthy
  • Able to provide informed consent

Exclusion

  • Active substance use disorder
  • Prior opioid use disorder
  • Opioid use within 30 days.

Key Trial Info

Start Date :

April 30 2019

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

September 3 2019

Estimated Enrollment :

20 Patients enrolled

Trial Details

Trial ID

NCT04301895

Start Date

April 30 2019

End Date

September 3 2019

Last Update

March 10 2020

Active Locations (1)

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Page 1 of 1 (1 locations)

1

University of California San Francisco

San Francisco, California, United States, 94143