Status:
UNKNOWN
Effects of Combined Aerobic and Resistance Training in Patients With Intermittent Claudication
Lead Sponsor:
University Of Perugia
Conditions:
Peripheral Arterial Disease
Endothelial Dysfunction
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
Exercise training improves walking capacity and regional perfusion in patients with Intermittent Claudication (IC). Endothelial Progenitor Cells (EPCs) and Endothelial Microparticles (EMPs) could play...
Eligibility Criteria
Inclusion
- history of stable intermittent claudication (PAD, stage II Fontaine)
- resting ankle-brachial index (ABI) \<0,9 and the presence of occlusion or significant stenosis at the color-Doppler duplex ultrasound scanning
Exclusion
- lower-limb ischemic rest pain or gangrene (Fontaine stages III and IV)
- inability to obtain the ABI value or to perform a walking test
- exercise tolerance limited by factors other than claudication (i.e., arrhythmias, cardiac symptoms or exaggerated blood pressure rise, severe obesity)
- end-stage liver or renal failure
- acute or chronic inflammatory conditions
- history of recent (\<6 months) acute coronary syndrome, cerebrovascular event or inducible myocardial ischemia
- treatment with drugs known to affect walking capacity, including calcium-channel blockers, β-blockers and angiotensin-converting enzyme inhibitors.
Key Trial Info
Start Date :
March 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2021
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04302571
Start Date
March 1 2020
End Date
January 1 2021
Last Update
March 27 2020
Active Locations (1)
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1
Ospedale "Santa Maria della Misericordia" di Perugia
Perugia, PG, Italy, 06132