Status:
COMPLETED
The Relation Between Quadriceps Muscle Layer Thickness and Nitrogen Balance for Nutrition Monitoring
Lead Sponsor:
Zagazig University
Conditions:
Trauma
Eligibility:
All Genders
18-60 years
Brief Summary
Loss of muscle mass is a major cause of intensive care unit-acquired weakness (ICU-AW) and is associated with delayed weaning; prolonged ICU and hospital stay and is an independent predictor of one ye...
Detailed Description
Protein catabolism and proteolysis, mainly in the skeletal muscles is highly accelerated in critical illness with severe acute inflammatory processes, such as sepsis, burns, and polytrauma patients. T...
Eligibility Criteria
Inclusion
- Anticipated to be mechanically ventilated to \>48hour and expected to Stay in ICU \> 4 days.
- No contraindication to early enteral nutrition.
- Enteral feeding in the first 24 hours after admission, with a minimum protein contribution of 1 gm / kg / day.
- We recruited only well nourished, previously healthy patients with no past history of nutritional problems.
Exclusion
- Patients with preexisting neuromuscular pathology, lower limb amputation, skeletal fractures or immobilization in the previous 2years.
- Patients with relevant Co-morbidities (renal, liver or heart disease or COPD), previous immune abnormalities including those receiving corticosteroids, and those with past or recent history of cancer.
- Patients with anuria owing to the difficulty in evaluating excreted urea nitrogen
- Whose ultrasound data will be missing or incomplete
- Pregnancy
- Patients who will not reach the goal in enteral protein intake for any reason (gastrointestinal intolerance, contraindication to enteral feeding or repeated interruptions of enteral feeding due to multiple surgical procedures) or those who start parenteral nutrition.
Key Trial Info
Start Date :
March 15 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2023
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT04303650
Start Date
March 15 2020
End Date
November 30 2023
Last Update
December 5 2023
Active Locations (1)
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1
Emergency and Surgical Intensive Care Units, Zagazig University Hospitals
Zagazig, Sharqia Province, Egypt, 44111