Status:
ACTIVE_NOT_RECRUITING
Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy
Lead Sponsor:
Abramson Cancer Center at Penn Medicine
Conditions:
Cardiotoxicity
Lung Cancer Stage III
Eligibility:
All Genders
18+ years
Brief Summary
This observational cohort will evaluate the cardiovascular effects of chemoradiation used to treat locally advanced, non-small cell lung cancer. Patients will be enrolled prior to the start of therapy...
Detailed Description
Lung cancer is both the most common malignancy worldwide and the leading cause of cancer death in the US. While radiation therapy is highly effective for many solid tumors, thoracic radiation therapy ...
Eligibility Criteria
Inclusion
- At least 18 years of age
- Histologically confirmed or clinically diagnosed non-small cell lung cancer where the plan is for definitive treatment that includes radiation
- Able to give written informed consent
Exclusion
- Pregnant or breast-feeding
- Prior treatment with anthracyclines
- Radiation treatment not expected to involve any heart exposure as determined by treating provider
- ECOG performance status greater than 2
- Vulnerable patients, including pregnant women and prisoners
- Contraindication to rest/vasodilator stress PET/CT, including: asthma with ongoing wheezing at time of enrollment; known Mobitz Type II AV block, 3rd degree AV block, or sick sinus syndrom, without a pacemaker; systolic blood pressure less than 90mmHg; known hypersensitivity to Regadenoson and adenosine; profound sinus bradycardia (heart rate less than 40bpm).
Key Trial Info
Start Date :
September 14 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
221 Patients enrolled
Trial Details
Trial ID
NCT04305613
Start Date
September 14 2020
End Date
December 1 2030
Last Update
October 2 2025
Active Locations (8)
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1
University of Alabama
Birmingham, Alabama, United States, 35233
2
The Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
3
Washington University School of Medicine
St Louis, Missouri, United States, 63110
4
Rutger's University / Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08901